Mesoblast (ASX:MSB) share price drops following third quarter update

It was an eventful but cash-burning quarter for Mesoblast…

| More on:
A worried doctor looks through a glass door.

Image source: Getty Images

You’re reading a free article with opinions that may differ from The Motley Fool’s Premium Investing Services. Become a Motley Fool member today to get instant access to our top analyst recommendations, in-depth research, investing resources, and more. Learn More

The Mesoblast limited (ASX: MSB) share price is under pressure on Thursday following the release of its third quarter update.

In early trade, the allogeneic cellular medicines company's shares are down 2.5% to $1.87.

How did Mesoblast perform in the third quarter?

For the three months ended 31 March, Mesoblast reported revenue of US$1.9 million. This was down 84% on the prior corresponding period due to significant one-off milestone revenue a year earlier. This means that year to date revenue now stands at US$5.46 million, down almost 83% on the same period last year.

This ultimately led to Mesoblast reporting a loss after tax of US$26.5 million for the quarter, which brought its financial year to date loss to US$76.75 million.

Fortunately, Mesoblast was able to raise US$110 million via a private placement in March. As a result, it was able to absorb these losses and finished the period with a cash balance of US$158.3 million. Management believes this is sufficient to meet its short-term goals, commitments, and ongoing operations during the next twelve months.

What else happened during the quarter?

Mesoblast was very busy during the quarter with its remestemcel-L therapy. It is seeking to use remestemcel-L to treat steroid-refractory acute graft versus host disease (SR-aGVHD) in children, and COVID-19 ARDS in adults. It is also seeking to gain approval to treat chronic low back pain with rexlemestrocel-L.

In respect to SR-aGVHD in children, Mesoblast continues to be in discussion with the United States Food & Drug Administration (FDA) through a well-established regulatory process. This may include a resubmission with a six-month review with the aim of achieving approval.

As for COVID-19 ARDS in adults, results from the randomised controlled trial of remestemcel-L in ventilator-dependent COVID19 patients with moderate/severe acute respiratory distress syndrome (ARDS) indicated that in the pre-specified population under 65 years old (n=123), those who received remestemcel-L had a significantly reduced mortality through to 60 days.

However, the trial was halted after the third interim analysis and 222 enrolled patients since the 30-day primary endpoint would not be attained. Management notes that in patients under 65 years, the benefit was further increased when remestemcel-L was used with dexamethasone as part of standard of care.

The trial also indicated that the mortality reduction by remestemcel-L in those under 65 years was accompanied by increased days alive off mechanical ventilation and reduced days in hospital

Finally, its rexlemestrocel-L trial in the treatment of chronic low back pain indicated that a single injection of rexlemestrocel-L plus a hyaluronic acid carrier may provide at least two years of pain reduction, with opioid sparing activity in patients using opioids at baseline.

Mesoblast's Chief Executive, Silviu Itescu, commented: "We are pleased with the recent clinical outcomes regarding our lead product candidate remestemcel-L and continue to progress our regulatory discussions with the aim of achieving approval. Our focus and top priority remains on successfully bringing remestemcel-L to children with the devastating complication of steroid-refractory acute graft versus host disease and adults fighting COVID-19 acute respiratory distress syndrome."

Should you invest $1,000 in Mesoblast Limited right now?

Before you buy Mesoblast Limited shares, consider this:

Motley Fool investing expert Scott Phillips just revealed what he believes are the 5 best stocks for investors to buy right now... and Mesoblast Limited wasn't one of them.

The online investing service he’s run for over a decade, Motley Fool Share Advisor, has provided thousands of paying members with stock picks that have doubled, tripled or even more.*

And right now, Scott thinks there are 5 stocks that may be better buys...

See The 5 Stocks *Returns as of 30 April 2025

James Mickleboro does not own Mesoblast shares. The Motley Fool Australia's parent company Motley Fool Holdings Inc. has no position in any of the stocks mentioned. The Motley Fool Australia has no position in any of the stocks mentioned. The Motley Fool has a disclosure policy. This article contains general investment advice only (under AFSL 400691). Authorised by Bruce Jackson.

More on Healthcare Shares

Two doctors wearing white coats look closely at a medical imaging x-ray as the share prices of ASX 200 healthcare shares improve in FY23
Healthcare Shares

Pro Medicus shares climb 33% in less than a month, have I missed the dip?

Pro Medicus shares have soared. Is it the right time to invest?

Read more »

Man with rocket wings which have flames coming out of them.
Share Gainers

Guess which ASX All Ords share just rocketed 19% on BIG news

Investors are sending this ASX All Ords share flying on Monday. But why?

Read more »

A young male ASX investor raises his clenched fists in excitement because of rising ASX share prices today
Healthcare Shares

Why is this ASX All Ords stock surging 14% today?

This stock is starting the week strongly. But why? Let's find out.

Read more »

A man has a surprised and relieved expression on his face. as he raises his hands up to his face in response to the high fluctuations in the Galileo share price today
Healthcare Shares

Guess which ASX All Ords stock is rocketing 58% on big US news

What is getting investors excited today? Let's find out.

Read more »

Cropped shot of an attractive young female scientist working on her computer in the laboratory.
Healthcare Shares

3 reasons to buy this quality ASX 200 healthcare share today

A leading expert expects this outperforming ASX 200 healthcare share will keep running hot.

Read more »

A woman reclines in a comfortable chair while she donates blood holding a pumping toy in one hand and giving the thumbs up in the other as she is attached to a medical machine to collect her blood donation.
Healthcare Shares

Brokers tip 4 ASX 200 healthcare shares to buy now

Healthcare is a defensive sector that can provide useful cover for investors when the market is volatile.

Read more »

Shot of a scientist using a computer while conducting research in a laboratory.
Healthcare Shares

How Trump's tariffs have created 'upside potential' for CSL shares

A leading expert says CSL shares are now looking ‘cheap’.

Read more »

Shot of a young scientist looking stressed out while working on a computer in a lab.
Healthcare Shares

Telix shares crash 8% on US FDA blow

This high-flying stock has been hit with some bad news.

Read more »